This immune boosting smoothie recipe employs the natural power of black elderberries, which have nearly double the anthocyanins as other berries. This special type of flavanoid promotes immune support, anti-inflammatory, anti-viral, and anti-cancer benefits.

Blended with antioxidant rich fruits to support a healthy immune system, this recipe is a winner.

purple smoothie getting poured into a glass.

For a few years, my family had no health insurance and I took a proactive approach to health care. We boosted our immune system to help us not get sick in the first place. From green smoothies to plant-based meals to natural remedies— we did anything we could to not get sick….and it worked.

Kids have started going back to school (mine included), restaurants are opening and new COVID cases are still making the headlines, it’s vital to build up your body’s natural defense: the immune system.

Table of Contents
  1. Where to Buy Elderberry Syrup
  2. Benefits
  3. Elderberry Syrup in a Smoothie
  4. How to Make an Immune Boosting Smoothie
  5. Immune Boosting Smoothie Recipe

One of the key immune supporting ingredients I added to our smoothies was elderberry syrup. I’ve partnered with Sambucol Black Elderberry Syrup to create a tasty immune boosting smoothie recipe.

Where to Buy Elderberry Syrup

You can find Sambucol Elderberry Syrup at Target, Costco, Amazon, major drug stores and also on the Sambucol website. It’s been flying off the shelves since COVID-19 became a pandemic, which is exciting to see more and more people lean towards the natural remedies world.

Ingredients in an elderberry smoothie including dragon fruit cubes, elderberry syrup, blackberries and banana.


Black elderberries are a natural remedy to boost the immune system. I first learned about it from a friend, who’s mom and grandmother used it. It’s a natural remedy passed on generation to generation because it has been shown to work.

This plant-powered elderberry syrup is rich in a particular antioxidant: flavonoids. Flavonoids help prevent damage from free radicals at the cellular level. A particular flavonoid, anthocyanins, is found heavily in black elderberries.

In fact, the United State Department of Agriculture found that black elderberries contain nearly twice the amount of anthocyanins compared with other berries. Some studies suggest that consuming elderberries can help support and maintain a healthy immune system. Elderberries are also a good source of vitamins A, B, and C, which are also important for immune function.

Immune Boosting Smoothie with Sambucol Elderberry Syrup.

Elderberry Syrup in a Smoothie

I’m sure you’ve noticed my favorite ingredient in this immune boosting smoothie is elderberry syrup. Along with the delicious berry flavor, elderberry syrup is packed with natural health benefits.

It’s important to note that black elderberry syrup is a dietary supplement. It isn’t intended to diagnose, treat, cure, or prevent any disease. Yet elderberry syrup is a natural remedy that my family has experienced the benefits of and I’m excited to share it with you today.

You can make your own DIY Elderberry Syrup Recipe, yet it takes more time and money. It’s just so convenient to keep Sambucol Elderberry Syrup on hand. Whatever way you go, you can use either syrup interchangeably in this immune boosting smoothie recipe.

Adding elderberry syrup to a smoothie recipe.

How to Make an Immune Boosting Smoothie

I came up with this unique recipe of fruits and other plants chosen specifically for their immune-supporting properties. I also wanted it to be something that my kids would happily drink. This smoothie does all that with a few fun ingredients.

If you’ve never had a smoothie with dragon fruit, it’s very similar to kiwi both in texture and flavor. A lot of grocery stores now carry frozen puree or cubed dragon fruit. You can use fresh or frozen in this immune boosting smoothie recipe.

Also, I included coconut water because I love that added nutrients. You can easily swap with water or almond milk in this smoothie, if preferred.

Immune boosting smoothie in a kitchenaid blender.

Depending on how many you’re making this smoothie for, increase the amount of elderberry syrup accordingly to make sure everyone gets some of it. Plus, the flavor of the elderberries really compliments this smoothie.

For more immune boosting recipes using Elderberry Syrup, check out my Elderberry Smoothie Popsicles and Immune Boosting Smoothie Cubes.

Don’t forget to rate + review this smoothie once you make it. I can’t wait to read your freedback!

4.90 from 107 votes

Immune Boosting Smoothie

Give your immune system a boost by blending up this vibrant purple powerhouse smoothie that combines Sambucol black elderberry syrup with antioxidant-rich blackberries and pitaya (dragon fruit). Bottoms up!
Prep: 5 minutes
Total: 5 minutes
Author: Jen Hansard
Course: Natural Remedy, Smoothie
Cuisine: Healing, Plant-Based, Vegan
Serves: 1



  • Place all ingredients into a blender.
  • Puree until smooth.
  • Serve immediately.



  • Other berries can be substituted for the blackberries. We recommend those high in antioxidants such as blueberries, raspberries, or cranberries.
  • Make sure to use at least 1 frozen fruit for a refreshingly cool smoothie.
  • Missing the leafy greens? Feel free to add up to 1 cup!


Calories: 260kcal, Carbohydrates: 55g, Protein: 4g, Fat: 3g, Saturated Fat: 1g, Polyunsaturated Fat: 1g, Monounsaturated Fat: 1g, Sodium: 325mg, Potassium: 1167mg, Fiber: 11g, Sugar: 34g, Vitamin A: 289IU, Vitamin C: 35mg, Calcium: 88mg, Iron: 3mg
Tried this recipe? Show me!Mention @SimpleGreenSmoothies or tag #SimpleGreenSmoothies!

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  1. I have heard great things about elderberry syrup and would love to try it myself!

  2. I swear by Sambucol! I always keep some in my medicine stash during cold season. I definitely believe it help to shorten colds and keep everyone healthier.

  3. 5 stars
    Yum! I am starting out as a first year teacher teaching preschoolers & I’m sure you know how many germs get passed around in those classrooms, even with them wearing face shields. My father in law is recovering from leukemia so we want to stay healthy so we can keep visiting him.

    1. What a time to be a first-year teacher! Good luck to you, Alexa, and stay healthy!!

  4. 4 stars
    I have heard such great things about elderberry syrup and would love to give it a try to help with inflammation and to support my immune system. Thank you for this great smoothie recipe to try!

  5. I want to give my family’s immune systems a boost for the sake of my mom who is in the super high risk category. We’re living with my parents while waiting to find a new home, and don’t want to pass anything on to her!

  6. 4 stars
    This sounds like such an interesting smoothie! I will have to give it a try! I’d like to give my teenage girls the syrup to strengthen their immunity as they go back to in-person school. They want to be in school so badly! It would help me feel better knowing their immune system is getting a boost.

    1. This smoothie would be a great way to help your daughters maintain a strong immune system as they go back to school! They’ll love the taste, also!! 🙂

  7. Looking forward to an immune boost, especially during the pandemic… haven’t had a chance to try this brand, as it’s always sold out when looking in stores.

    1. I think it’s always sold out because it’s such a great product!

  8. I have not yet tried this one but I love this color! I am always looking for ways to help support my health and the health of my family and friends, especially during flu season. A balanced immune system is so important to health which makes for Happy Holidays!

  9. 5 stars
    I’d like to give my family’s immune system a boost so my son can stay in his kindergarten class. If he has any symptoms, he has to stay home possibly for weeks depending on the symptom.

  10. Anything to help me get better blood test results – I have been told after the latest blood draw I had so many health concerns that a healthy diet fix might get me better and better lymphatic tests – so, I do know about this great health product and wish to have some right now – oh what can help me ??? maybe, this can get me some better medical results hopefully.

    1. I know about a great product that can help you get started, Regina. Our 7-Day Green Smoothie Challenge! Our challenge will help you find a simple + healthy habit that transforms your body. Yes, simply adding one green smoothie to your normal diet for one week will give you more energy and help you naturally crave healthier foods all day long. The best part about it is that it’s free! Go here to sign up: 🙂

  11. I haven’t tried this smoothie but it looks bright and healthy!
    I have been wanting to make my own elderberry syrup but the price went up this year on the berries because of the pandemic.
    In these times we need all the help we can give our immune system , the best way is prevention and smoothies like these are key. I have been educating my adult kids to nurture their body by eating veggies and fruits and nuts to give our stressed bodies some help. Elderberry Syrup is always available in our home. I have tried following the 7 week smoothies challenge several times. But we tend to stick to our favorite ones after one or two different variations. But we try!

    1. Def give this smoothie a try and let us know what you think!

  12. Another excellent way to enhance my natural immunities is of great interest to me!

    1. This smoothie is a great way to strengthen and support your immune system!

  13. Living in Oklahoma, the weather changes so rapidly I am constantly having to take an antihistamine. I would so much rather be taking something natural rather than a pill. I would love to try this, because the recipe sounds delicious!

  14. I’d love to try. With 3 autoimmune diseases, this would be right up my alley.

    1. This smoothie is a great way to help support the immune system. 🙂