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When cold season hits—or whenever I want to support my immune system—I reach for whole foods instead of overpriced powders. These frozen immunity cubes are made with vitamin C–rich fruits and vegetables that blend easily into smoothies and taste naturally sweet and bright. They’re an easy way to keep nutrient-dense ingredients on hand, so supporting your body feels simple, not complicated.
Table of Contents
Why These Ingredients Work Together
This blend focuses on fruits and vegetables naturally high in vitamin C and antioxidants:
- Oranges: Juicy and refreshing, they provide natural sweetness and liquid for blending.
- Papaya: Rich in vitamin C and digestive enzymes.
- Pineapple: Adds tropical flavor and additional immune-supporting nutrients.
- Mango: Brings natural sweetness and a smooth texture.
- Orange cauliflower: It’s packed with high levels of beta-carotene, containing roughly 25 times more vitamin A than the white variety and also a vitanin c
Together, these ingredients create a concentrated fruit blend that freezes beautifully and blends seamlessly into smoothies.
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How to Make Frozen Immunity Cubes
Frozen immunity cubes make healthy habits easier to keep. You prep once, freeze, and then have nutrient-dense ingredients ready whenever you need them. No supplements, no powders—just whole foods doing what they do best.
- Place all ingredients into a blender in the order listed.
- Blend until completely smooth. The oranges usually provide enough liquid, but add a splash of water or orange juice if needed.
- Spoon the mixture into two 16-well ice cube trays, filling each well with about 2–2½ tablespoons.
- Freeze until solid, at least 3–4 hours or overnight.
- Transfer frozen cubes to an airtight, freezer-safe container.
How to Use Immunity Cubes
Add 4 immunity cubes to your favorite smoothie to replace about ½ cup of fruit. Adjust up or down depending on your taste and texture preferences. These cubes are especially helpful when you want an immune-supporting boost without extra prep time.
More Smoothie Cube Recipes
If you love the idea of smoothie cubes, there are plenty of ways to use them for targeted support. My anti-inflammatory blender bombs focus on ingredients that help calm inflammation, while antioxidant smoothie cubes pack as many protective nutrients as possible into one easy add-in. Electrolyte cubes are perfect for post-workout smoothies when your body needs natural hydration support, and alkaline freezer cubes bring a variety of greens together for an easy, everyday boost.
I’d love to hear how it turned out in the comment box below. Your feedback helps me and all the readers in this community. And if you’re interested in more plant-based recipes (and exclusive content), sign up for my weekly recipe newsletter.
Frozen Immunity Cubes (Vitamin C Smoothie Cubes)
Ingredients
- 2 oranges peeled and halved
- 1 cup papaya cubed or sliced
- 1 cup pineapple cubed
- 1 mango cubed
- 1 cup orange cauliflower florets see notes
Instructions
- Place ingredient into the blender in the order given.
- Puree until smooth. It should not need any liquid because of the oranges, but if it does, add a little water or orange juice.
- Spoon into two 16-well ice cube trays, about 2 to 2 1/2 tablespoons per well. Freeze until firm, at least 3-4 hours, or overnight. Transfer to an airtight, freezer-safe container. Will keep for several weeks in a normal freezer, or up to six months in a deep freezer.
- When ready to use, add 4 Vitamin C Smoothie Cubes to your favorite smoothie to replace 1/2 cup fruit. Add more or less cubes depending on preference.
Helpful Tools
Notes
- Substitute any vitamin C-rich fruit or vegetable, such as strawberries, sweet bell pepper, cauliflower, cantaloupe, kiwi, or others in place of 1+ of the fruits listed above. Nutrition information will change with any substitutions.
- Frozen fruit and cauliflower can be substituted for the fresh fruit.
I’m obsessed with your smoothie cube recipes. Thanks for changing my smoothie game!
It’s our joy, Christa!
What can I use instead of papaya?
Some great swaps for papaya are pineapple, mango, peaches or nectarines. Let us know which you blended and how you liked it!
Wahoo I have leant a lot from u just now I will try one
Yummy and such a nice way to add some coolness to a smoothie.
Great for the winter to get that extra boost of vitamin C and great for the summer to get that refreshing tropical fruit taste!
These are delicious!!
They are and great to have on hand to throw in your smoothies! 🙂
I have a lemon tree and had LOADS of lemons to use, I juiced and froze them in cubes for future Morning Tonics. I was just wondering this morning about freezing the juice of oranges and grapefruits a neighbor gave me. I hadn’t thought about blending the entire orange for cubes. I use frozen pineapple and mango from Trader Joes, so I’m not sure I’d need to blend those into cubes with the oranges. I likely won’t get out for papaya or cauliflower, so I think I’ll be freezing a lot of just plain orange cubes.
As someone else mentioned, I’ll need a bigger freezer!
Hey Kimberly! First of all, I’m so jealous you have a lemon tree. It would be so awesome to have fresh lemons at your fingertips!!
I think it’s a great idea to blend and freeze the oranges and grapefruits. If you plan to use them in your smoothies anyway, I think blending them as opposed to juicing them would be the better option. That way, you’ll get the fiber and all the awesome nutrients that are in the pith (the white part). I’d recommend zesting them (you can freeze the zest as well for future smoothies and/or other recipes), then peeling them, and then blending and freezing.
Done….in the freezer waiting to be bagged. Used regular cauliflower since the orange one is not available right now. Had a bit left over which will be a tasty frozen dessert treat.
Nice job!
Utilizing the Smoothie Cubes idea for all seasons.
So convenient. Great idea.
Sorry, went back and re-read the notes that I somehow skipped over. Yes! You can substitute frozen for fresh!
No worries, hope the cubes worked out great for you!
Silly question perhaps but can you use frozen fruit to make these cubes?
Not a silly question and yes, you definitely can use frozen fruit to make these!
So love this idea.
I buy washed and ready to use mixed green leaves in bags, roll them up tight and freeze the just slice off 2-3 inches and add to the blender. Leaves stay fresh and money saved.
Also bags of washed mint leaves and chopped celery including the leaves.
Pomegranates seeded and frozen on trays then bagged. Need a bigger freezer
Wow, Sally! Your prep work is on point!
Great idea! What is the ‘orange cauliflower’ (last ingredient)? Also, do I need to boil the cauliflower in water first?
Hey Ankita,
That is a type of cauliflower. If you do not have orange cauliflower then I would suggest using regular or the other suggestions in the “notes” section.
Hope that helps!
Awesome! I love this idea as I hate taking supplements in “pill” form.
I’m going to add a couple to my water once a day.
I am the same way. Show me how I can consume this in my diet so I don’t have to take supplements or a pill to get it. I prefer the raw and real part of it and that is exactly what this is! Enjoy!! 🙂
Your book was what got me started on the green journey. Love it !
My concern is raw cauliflower???? In India, we often have tiny worm infestation in the florets, so Indian cuisine rarely uses raw florets. What other substitutes can we use for the cauliflower please ?
Hey Smita,
Oh gosh I am sorry to hear that. For this recipe we do not have a substitute for cauliflower so I would just leave it out completely.
Interesting idea. if nothing else it is a least tasty !
How effective is the potency of the Vitamin C in this process?
Hey Jeff,
This way of getting your vitamin C is very effective since you are getting it directly from the source.
WOW!! I’m blown away by this recipe + can’t wait to get in the kitchen. This are going to be amazing when I feel a cold coming on!
Thanks Amanda!!
It’s crazy to think that something so delicious can be packed with tons of vitamins too!!
Never thought of doing this before… Do you think that I need to use the cubes only with certain recipes or combinations?
Hey Sarah,
I would add these into smoothies that have a tropical feel to it. Like our Beginner’s Luck!!
That color is so beautiful! I’m just imagining how good these would taste all blended up. If it weren’t for my daily green smoothies, I’m not sure I’d be getting all of my vitamin C in. Gonna make a batch of these stat!
Hey are so beautiful and vibrant!! I love the splash of color it adds to my freezer. You are going to love these when you try them 🙂
I love this idea! I’m definitely using this to keep the summer colds and back to school sniffles away. How long will they stay good in the freezer?
Hey Kim,
This will definitely help with keeping those back to school germs away!! If you store these in a reusable freezer bag they should stay good for 3 months. Although I have a feeling you will use them up before then 🙂
Hope that helps!
I love this idea so much!!!! I’ve often wondered how I can boost my smoothies when I have a cold and I think this is the perfect solution!!! I could see this smoothie cube booster being really good in Beginner’s Luck… my fav of all your smoothies. Do you have any tips for storing these in my freezer? I’m wonder what would be the best way …
Hey Dani,
This would taste delicious in Beginner’s Luck so I would definitely give it a try. The best way would be to freeze these in your typical ice trays and then store them in a reusable freezer bag 🙂